INCREASED EXPRESSION OF THE IMMUNOPROTEASOME SUBUNITS PSMB8 AND PSMB9 BY CANCER CELLS CORRELATE WITH BETTER OUTCOMES FOR TRIPLE-NEGATIVE BREAST CANCERS

Abstract Proteasome dependency is a feature of many cancers that can be targeted by proteasome inhibitors.For some cancer types, notably breast cancer and triple-negative breast cancer (TNBC), high mRNA expression of a modified form of the proteasome, called the wella color charm 050 cooling violet immunoproteasome (ImP), correlates with better out

As a new and great source of potential energy storage technology, the spiral spring energy storage (SSES) technology uses a permanent magnet synchronous machine (PMSM) to tighten or release the spiral spring for energy conversion.In allusion to the feature of simultaneous variations in torque and inertia for spiral springs in operation, it is diffi

The Last Millennium Reanalysis (LMR) utilizes an ensemble methodology to assimilate paleoclimate data for the production of annually resolved climate field reconstructions of the Common Era.Two key elements are the focus of this work: the set of assimilated proxy records and the forward models that map climate variables to proxy measurements.Result

Cold-active enzymes increase their catalytic efficiency at low-temperature, introducing structural flexibility at or near the active sites.Inevitably, this feat seems to be accompanied by lower thermal stability.These characteristics have made cold-active enzymes into attractive targets for the industrial applications, since they could reduce the e

Abstract Since 2004 there has been an increased recognition of the importance of Neglected Tropical Diseases (NTDs) as impediments to development.These diseases are caused by a variety of infectious agents - viruses, bacteria and parasites - which cause a diversity of clinical conditions throughout the tropics.The World Health Organisation (WHO) ha